Correction: Association analysis using somatic mutations
نویسندگان
چکیده
منابع مشابه
Correction: Somatic mutations in cancer development
Since publication of Environmental Health 2011, 10(Suppl 1):S12 [1] it has been noticed that titles and captions for the figures and tables were incorrectly applied. In this full-length correction article, figures and tables have been renumbered with legends and captions applied appropriately. Some minor typographical errors have also been corrected. The inconvenience caused to readers by prema...
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We have examined the nature and localization of somatic mutations in three tc transgenes cloned from IgG-secreting hybridomas . All of the mutations identified were single base substitutions. Mutations were localized to the variable (V) region and its flanking sequences. In every case, the nuclear matrix association region, K enhancer, and C gene were spared . These data indicate that the rearr...
متن کاملAnalysis of somatic mutations in kappa transgenes
We have examined the nature and localization of somatic mutations in three kappa transgenes cloned from IgG-secreting hybridomas. All of the mutations identified were single base substitutions. Mutations were localized to the variable (V) region and its flanking sequences. In every case, the nuclear matrix association region, kappa enhancer, and C gene were spared. These data indicate that the ...
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KRAS mutations are major factors involved in initiation and maintenance of pancreatic tumors. The impact of different mutations on patient survival has not been clearly defined. We screened tumors from 171 pancreatic cancer patients for mutations in KRAS and CDKN2A genes. Mutations in KRAS were detected in 134 tumors, with 131 in codon 12 and only 3 in codon 61. The GGT>GAT (G12D) was the most ...
متن کاملSomatic mutations and proteins
A large body of data has now been accumulated concerning the ways in which heritable mutations can affect protein structure. Such mutations are usually presumed to arise in the germ line, and are studied by progeny analyses of various types. Today, I would like to consider how somatic mutations might be genetically predisposed and thereby made available to an organism during its adaptation to e...
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ژورنال
عنوان ژورنال: PLOS Genetics
سال: 2018
ISSN: 1553-7404
DOI: 10.1371/journal.pgen.1007848